The Gresini rider handed long-time chief Jack Miller on the manufacturing facility crew Ducati late on to take his first podium since his debut win within the season opener in Qatar.
He’s MotoGP’s first repeat winner in 2022 and takes a five-point lead within the championship.
Miller took the lead from poleman Jorge Martin off the road, however Bastianini steadily chipped away on the Australian’s lead earlier than passing him on lap 16.
Suzuki’s Alex Rins pulled off a last-lap transfer on Miller into the penultimate nook to grab second, shifting into second within the standings.
His team-mate Joan Mir was simply 1.6s away from the ultimate podium spot in fourth as Bagnaia may solely handle fifth having began from the entrance row.
After a lap one catastrophe, Marquez recovered to sixth on the chequered flag in a chic cost by way of the pack.
Enea Bastianini, Gresini Racing
Photograph by: Gold and Goose / Motorsport Images
Over the ultimate few excursions, Marquez and Quartararo engaged in a battle harking back to their 2019 race fights – although the pair almost got here to blows on the penultimate lap when Marquez had a second rounding Flip 6 and nearly touched Quartararo.
Marquez had taken sixth from the Yamaha rider on lap 14, with the Frenchman attempting to combat again after they nearly touched on lap 19.
The second despatched Quartararo out vast into Flip 7 and allowed Marquez to return again by way of to take sixth by simply zero.143s.
Martin pale to a disappointing eighth in the long run forward of Zarco, whereas Maverick Vinales took high Aprilia honours from team-mate Aleix Espargaro in 10th late on.
2022 MotoGP Americas GP: Race outcomes